Information Minister Hamza Almustafa and Agriculture Minister Amjad Badr were replaced by Khaled Fawaz Zaarour and Bassel Hafez al-Sweidan respectively.
Zaarour was head of the media faculty at the Damascus University before his appointment.
The reasons behind the overhaul are unclear.
The Syrian transitional cabinet created in March 2025 came after the ouster of longtime ruler Bashar al-Assad in 2024, and was dominated by Sharaa’s inner circle.
Sharaa also appointed new governors for several provinces including Homs, Quneitra and Latakia and Deir Ezzor.